The Effect of Testosterone on Serum Lipid Profiles, Glucose, Insulin and Leptin: A Experimental Study Based Animal Model

Background: Disruption in the endocrine system can cause many diseases. Based on this, the imbalance of sex hormones such as testosterone can change many serum factors. In this study, we examined the effect of testosterone on leptin levels, lipid profiles, and ultimately insulin resistance. Materials and Methods: Twenty one adult rats were divided into three groups of 7, including control group (C), olive oil group (O), and olive oil and testosterone group (OT). In the O and OT groups, they received olive oil and olive oil in combination with testosterone injection at the dose of 2 mg/kg/day, respectively. To evaluate the effects of hormonal imbalance on insulin resistance, various parameters such as leptin, triglyceride, cholesterol, glucose, and insulin were assessed. Results: The results showed that Triglyceride (TG) and insulin levels were higher in the OT group compared to the other two groups (P<0.05). In contrast, leptin and cholesterol levels were higher in group C compared to the other two groups (P<0.05) and glucose levels were higher in group O compared to the other two groups (P=0.01). Conclusion: In general, it can be said that testosterone can change serum lipid profiles, leptin, insulin, and glucose.