Immunoaging at Early Ages Could Drive a Higher Comorbidity Burden in People with HIV on Antiretroviral Therapy Compared with the Uninfected Population
This is an observational, cross-sectional, comparative case-control, pilot study aimed at assessing the impact of HIV infection and age on immunological markers in people with HIV (PWH) on antiretroviral therapy (ART). The study included 40 PWH on ART, divided into two age groups (40-45 years vs. ≥60 years), and 30 HIV-uninfected controls matched by sex and age. The results show that older PWH on ART had more comorbidities and a higher frequency of CD8 T cells compared to older controls, with a significant decrease in CD8 naïve T cells with age. Additionally, younger PWH on ART exhibited higher frequencies of activated CD8 T cells and elevated levels of inflammatory markers (sCD14, IL-6) compared to age-matched controls, with values similar to those of older PWH on ART. These findings suggest that younger PWH on ART may experience accelerated immunoaging, highlighting the need for early interventions in this population.
Authors
- Eugènia Negredo (ORCID: https://orcid.org/0000-0001-5298-1734)
- Cora Loste (ORCID: https://orcid.org/0000-0002-5406-1875)
- Ana Raquel Ortega Martínez (ORCID: https://orcid.org/0000-0002-4336-6593)
- Macedonia Trigueros (ORCID: https://orcid.org/0000-0003-4156-1018)
- F Muñoz-López (ORCID: https://orcid.org/0000-0003-1789-1658)
- Jordi Puig (ORCID: https://orcid.org/0000-0002-4075-0346)
- Marta Massanella (ORCID: https://orcid.org/0000-0002-3326-151X)
- Víctor Urrea (ORCID: https://orcid.org/0000-0002-2577-856X)
- Anna Bonjoch (ORCID: https://orcid.org/0000-0002-5343-2881)
- Sandra González (ORCID: https://orcid.org/0009-0002-0884-4200)
- Marta Martín
- Patricia Echeverría (ORCID: https://orcid.org/0009-0004-9148-1731)
Institutions
- Universitat de Vic - Universitat Central de Catalunya (ES)
- Universitat Autònoma de Barcelona (ES)
- Instituto de Salud Carlos III (ES)
- IrsiCaixa (ES)
- Centro de Investigación Biomédica en Red (ES)
- Hospital Universitari Germans Trias i Pujol (ES)
- Fundació Lluita contra les Infeccions (ES)
Publication Details
- Journal
- International Journal of Molecular Sciences
- Published
- 2024-10-11
- DOI
- https://doi.org/10.3390/ijms252010930
- Citations
- 2
- Primary Topic
- HIV-related health complications and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.38
Funders
- Ministerio de Ciencia e Innovación