Ph<sub>3</sub>P═O-Catalyzed Reductive Deoxygenation of Alcohols
Reductive deoxygenation of alcohols is particularly challenging because of the high bond dissociation energy of the C-OH bond and the poor leaving ability of the hydroxyl group. Herein we describe a Ph<sub>3</sub>P═O-catalyzed reductive deoxygenation of benzyl alcohols with PhSiH<sub>3</sub> under an air atmosphere within 30 min of reaction time. The use of catalytic loading of Ph<sub>3</sub>P═O enhances the practicality of this protocol.
Authors
- Yu Sun (ORCID: https://orcid.org/0000-0003-4269-7187)
- Jin‐Hong Lin (ORCID: https://orcid.org/0000-0002-7000-9540)
- Ji‐Chang Xiao (ORCID: https://orcid.org/0000-0001-8881-1796)
- Qiang Li (ORCID: https://orcid.org/0000-0001-9833-2836)
- Mu-Xian Fu
Institutions
- Shanghai University (CN)
- Shanghai Institute of Organic Chemistry (CN)
- Innovative Research (United States) (US)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-10-11
- DOI
- https://doi.org/10.1021/acs.joc.4c01847
- Citations
- 7
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 1.11
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality
- National Key Research and Development Program of China