DNA polymorphisms in inflammatory and endocrine signals linked to frailty are also associated with obesity: data from the FRASNET cohort
Frailty-related SNPs contribute to obesity in community-dwelling older adults. We identified a novel association between adducin SNPs and visceral fat, which has not been previously reported. Detecting genetic predispositions to obesity and frailty early could aid in identifying individuals at risk, facilitating the adoption of preventive interventions. This represents an initial step toward promoting early intervention strategies.
Authors
- Sarah Damanti (ORCID: https://orcid.org/0000-0002-2399-3688)
- Rebecca De Lorenzo (ORCID: https://orcid.org/0000-0002-1281-7996)
- Chiara Lanzani (ORCID: https://orcid.org/0000-0002-5332-4012)
- Simona Santoro
- Marco Simonini (ORCID: https://orcid.org/0000-0003-0664-4600)
- Cristiano Magnaghi (ORCID: https://orcid.org/0000-0003-1151-0527)
- Lorena Citterio (ORCID: https://orcid.org/0000-0001-6455-2291)
- Angelo A. Manfredi (ORCID: https://orcid.org/0000-0001-8370-6970)
- Paolo Manunta (ORCID: https://orcid.org/0000-0003-3976-9696)
- Laura Zagato (ORCID: https://orcid.org/0000-0002-0441-2120)
- Giordano Vitali
- Elena Brioni (ORCID: https://orcid.org/0000-0003-3643-3601)
- Patrizia Rovere‐Querini (ORCID: https://orcid.org/0000-0003-2615-3649)
- Eleonora Senini
- Marco Messina
- Mariapia Ruggiero
Institutions
- Vita-Salute San Raffaele University (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2024-10-11
- DOI
- https://doi.org/10.3389/fendo.2024.1412160
- Citations
- 2
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.65
Funders
- European Commission
- Fondazione Cariplo