Associations of Circulating ANGPTL3, C-Terminal Domain–Containing ANGPTL4, and ANGPTL3/8 and ANGPTL4/8 Complexes with LPL Activity, Diabetes, Inflammation, and Cardiovascular Mortality
ANGPTL3/8 potently inhibited GPIHBP1-LPL enzymatic activity, consistent with its positive association with serum lipids. However, ANGPTL3/8, LDL-C, and triglyceride levels were not associated with cardiovascular death in the LURIC and getABI cohorts. In contrast, concentrations of ANGPTL4/8 and particularly CD-ANGPTL4 were positively associated with inflammation, the prevalence of diabetes, and cardiovascular mortality.
Authors
- Winfried März (ORCID: https://orcid.org/0000-0001-6083-8946)
- Martin Rief (ORCID: https://orcid.org/0000-0002-7378-2846)
- Heribert Schunkert (ORCID: https://orcid.org/0000-0001-6428-3001)
- Günther Silbernagel (ORCID: https://orcid.org/0000-0001-9323-329X)
- Deven Lemen (ORCID: https://orcid.org/0009-0004-4131-9760)
- Ulrike Sonja Trampisch (ORCID: https://orcid.org/0000-0002-6030-3383)
- Hans J. Trampisch (ORCID: https://orcid.org/0000-0001-9136-1079)
- Yan Chen (ORCID: https://orcid.org/0000-0001-9311-6077)
- Yuewei Qian (ORCID: https://orcid.org/0000-0003-0584-4723)
- Hongxia Li (ORCID: https://orcid.org/0000-0002-1440-1345)
- Graciela Delgado (ORCID: https://orcid.org/0000-0002-1272-7210)
- Hubert Scharnagl (ORCID: https://orcid.org/0000-0002-2750-006X)
- Robert J. Konrad (ORCID: https://orcid.org/0000-0003-0923-0542)
- Mark A. Sarzynski (ORCID: https://orcid.org/0000-0001-6705-0668)
- Marcus E. Kleber (ORCID: https://orcid.org/0000-0003-0663-7275)
- Henrik Rudolf (ORCID: https://orcid.org/0000-0001-9114-3805)
- Andreas Stang (ORCID: https://orcid.org/0000-0001-6363-9061)
- Angela P. Moissl (ORCID: https://orcid.org/0000-0003-0302-2136)
- Yuejun Zhen (ORCID: https://orcid.org/0000-0002-0162-5665)
- Yi Wen (ORCID: https://orcid.org/0000-0003-4862-6427)
- Boerge Schmidt
- Raimund Erbel
Institutions
- Boston University (US)
- Synlab Czech (Czechia) (CZ)
- Massachusetts Department of Public Health (US)
- University of South Carolina (US)
- Eli Lilly (United States) (US)
- Zimmer Biomet (Netherlands) (NL)
- Medical University of Graz (AT)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Institut für Medizinische Informatik, Biometrie und Epidemiologie (DE)
- Essen University Hospital (DE)
- Synlab (Germany) (DE)
- Ludwig Boltzmann Institute Applied Diagnostics (AT)
- Deutsches Herzzentrum München (DE)
- University Medical Centre Mannheim (DE)
- University of Rostock (DE)
- University of Duisburg-Essen (DE)
- Friedrich Schiller University Jena (DE)
- Ruhr University Bochum (DE)
Publication Details
- Journal
- Circulation
- Published
- 2024-10-11
- DOI
- https://doi.org/10.1161/circulationaha.124.069272
- Citations
- 19
- Primary Topic
- Lipid metabolism and disorders
- Type
- article
- Field-Weighted Citation Impact
- 7.64