Gastrointestinal stromal tumors regulate macrophage M2 polarization through the MIF/CXCR4 axis to immune escape
These findings identify that macrophages are the most abundant infiltrating cells in GIST. The MIF/CXCR4 axis is the most common ligand-receptor interaction between macrophages and tumor cells. GIST cells can regulate macrophage M2 polarization through the MIF/CXCR4 axis.
Authors
- Rui Xu (ORCID: https://orcid.org/0009-0004-1000-9903)
- Xiaoting Wu (ORCID: https://orcid.org/0000-0001-8011-9324)
- Rui Zhao (ORCID: https://orcid.org/0000-0003-1783-4610)
- Yingxin Yang
- Xu-dan Lei
- Shuomeng Xiao
- Yuan Xie
Institutions
- University of Electronic Science and Technology of China (CN)
- Sichuan University (CN)
- Sichuan Cancer Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-10-11
- DOI
- https://doi.org/10.3389/fimmu.2024.1431535
- Citations
- 10
- Primary Topic
- Gastrointestinal Tumor Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.64