YAP Overcomes Mechanical Barriers to Induce Mitotic Rounding and Adult Cardiomyocyte Division
Our data reveal that YAP5SA overcomes the mechanically constrained myocardial microenvironment to induce mitotic rounding with cardiomyocyte division, thus providing new insights into the in vivo mechanisms that maintain cell cycle quiescence in adult mammals.
Authors
- Matthew C. Hill (ORCID: https://orcid.org/0000-0003-4578-3873)
- Vaibhav Deshmukh (ORCID: https://orcid.org/0000-0002-0087-7545)
- Yuka Morikawa (ORCID: https://orcid.org/0000-0002-4571-8409)
- J H Kim (ORCID: https://orcid.org/0000-0002-4491-212X)
- James F. Martin (ORCID: https://orcid.org/0000-0002-7842-9857)
- Shijie Liu (ORCID: https://orcid.org/0000-0002-2597-5416)
- Gang Li (ORCID: https://orcid.org/0000-0001-9661-8304)
- Lin Liu (ORCID: https://orcid.org/0000-0002-0343-6286)
Institutions
- Broad Institute (US)
- Valve (United States) (US)
- Baylor College of Medicine (US)
- Massachusetts General Hospital (US)
- Baylor School (US)
- Baylor Genetics (US)
Publication Details
- Journal
- Circulation
- Published
- 2024-10-11
- DOI
- https://doi.org/10.1161/circulationaha.123.066004
- Citations
- 17
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 5.54
Funders
- Texas Heart Institute