Microglial responses partially mediate the effect of Aβ on cognition in Alzheimer's disease
This was a longitudinal study of amyloid beta (Aβ), microglial responses, and global cognitive performance. Aβ and microglial responses both affect cognition in early Alzheimer's disease. Microglial response partially mediates the effect of Aβ on cognition in later stages.
Authors
- Jeppe L. Schaldemose (ORCID: https://orcid.org/0000-0002-3088-2898)
- Hanne Gottrup (ORCID: https://orcid.org/0000-0003-2681-6174)
- Joel Aanerud
- David J. Brooks (ORCID: https://orcid.org/0000-0003-2602-2518)
- Simon Fristed Eskildsen (ORCID: https://orcid.org/0000-0003-4242-9158)
- Peter Parbo (ORCID: https://orcid.org/0000-0002-5792-1607)
- Pernille Louise Kjeldsen (ORCID: https://orcid.org/0000-0003-3335-0261)
- Lasse Stensvig Madsen (ORCID: https://orcid.org/0000-0002-5721-9885)
- Rola Ismail (ORCID: https://orcid.org/0000-0003-0837-6603)
- Kim Vang Hansen (ORCID: https://orcid.org/0000-0002-5665-3284)
Institutions
- Aarhus University (DK)
- Aalborg University Hospital (DK)
- Odense University Hospital (DK)
- Aarhus University Hospital (DK)
- Lillebaelt Hospital (DK)
- Newcastle University (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-10-11
- DOI
- https://doi.org/10.1002/alz.14298
- Citations
- 10
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.27
Funders
- Eli Lilly and Company
- Lundbeckfonden
- H. Lundbeck A/S