The HOPE4MCI study: AGB101 treatment slows progression of entorhinal cortex atrophy in <i>APOE</i> ε4 non‐carriers with mild cognitive impairment due to Alzheimer's disease
AGB101 slows entorhinal cortex (ERC) atrophy in apolipoprotein E (<i>APOE</i>) ε4 non-carriers with mild cognitive impairment (MCI) due to Alzheimer's disease (AD).Slowing ERC atrophy by AGB101 is associated with less Clinical Dementia Rating Sum of Boxes decline.Slowing ERC atrophy by AGB101 is associated with lower neurofilament light chain.AGB101 treatment reduces neurodegeneration in <i>APOE</i> ε4 non-carriers with MCI due to AD.
Authors
- Nisha Rani (ORCID: https://orcid.org/0000-0003-4667-2534)
- Michela Gallagher (ORCID: https://orcid.org/0000-0002-9585-6500)
- Richard C. Mohs (ORCID: https://orcid.org/0000-0002-3765-6287)
- Arnold Bakker (ORCID: https://orcid.org/0000-0003-0417-641X)
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- AgeneBio (United States) (US)
Publication Details
- Journal
- Alzheimer s & Dementia Translational Research & Clinical Interventions
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1002/trc2.70004
- Citations
- 3
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- National Science Foundation
- Johns Hopkins University
- National Institutes of Health