Loss of NAT10 Reduces the Translation of <i>Kmt5a</i> mRNA Through ac4C Modification in Cardiomyocytes and Induces Heart Failure
Our study highlights the significance of NAT10 in cardiomyocyte physiology, demonstrating that NAT10 loss is sufficient to induce cardiomyocyte apoptosis and heart failure. NAT10 regulates the translational efficiency of <i>Kmt5a</i>, a key mediator, through mRNA ac4C modification during heart failure.
Authors
- Ting Xu (ORCID: https://orcid.org/0000-0001-6123-9814)
- Jing‐Song Ou (ORCID: https://orcid.org/0000-0001-5517-3142)
- Zhan‐Peng Huang
- Xiaodong Zhuang (ORCID: https://orcid.org/0000-0001-6508-8507)
- Tailai Du (ORCID: https://orcid.org/0000-0002-8762-5569)
- Xinxue Liao (ORCID: https://orcid.org/0000-0001-7631-1866)
- Demeng Chen (ORCID: https://orcid.org/0000-0001-7230-2495)
- Chen Liu (ORCID: https://orcid.org/0000-0002-9818-0454)
- Jiangui He
- Xin He
- Huimin Zhou (ORCID: https://orcid.org/0000-0001-8297-2003)
- Jialing Wu (ORCID: https://orcid.org/0000-0001-9489-4794)
- Yugang Dong (ORCID: https://orcid.org/0000-0002-3072-5040)
- Youchen Yan
- Shuibin Lin
- Yan Li (ORCID: https://orcid.org/0000-0003-2450-3836)
Institutions
- Sun Yat-sen University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2024-10-11
- DOI
- https://doi.org/10.1161/jaha.124.035714
- Citations
- 11
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.57