TLR4/TRIF/Caspase-8/Caspase-1 Pathway in Choroidal Endothelial Cells Promotes Choroidal Neovascularization
The findings of this study indicate that caspase-8 plays a crucial role in promoting choroidal neovascularization by activating interleukin-1β and interleukin-18 through the toll-like receptor 4/TIR domain-containing adaptor molecule 1/caspase-8/caspase-1 pathway in choroidal endothelial cells. Therefore, targeting caspase-8 may hold promise as a therapeutic approach for neovascular age-related macular degeneration.
Authors
- Ying Yang (ORCID: https://orcid.org/0009-0002-9296-348X)
- Shenglai Zhang
- Aimin Sang (ORCID: https://orcid.org/0000-0002-9669-403X)
- Xiaowei Yang (ORCID: https://orcid.org/0000-0002-4610-3318)
- Jia Chen (ORCID: https://orcid.org/0000-0002-4242-2899)
- Shu Su (ORCID: https://orcid.org/0000-0002-3362-2549)
Institutions
- Nantong University (CN)
- Soochow University (CN)
- Affiliated Hospital of Nantong University (CN)
Publication Details
- Journal
- Current Eye Research
- Published
- 2024-10-11
- DOI
- https://doi.org/10.1080/02713683.2024.2409885
- Primary Topic
- Ocular Diseases and Behçet’s Syndrome
- Type
- article
- Field-Weighted Citation Impact
- 0.00