<i>APOE ε</i>4 carrier status moderates the effect of lifestyle factors on cognitive reserve
Mindfulness and social engagement have increased cognitive reserve in APOE ε4 carriers. Study uses residual scores from Cognivue Clarity tests to estimate cognitive reserve. APOE ε4 carriers show stronger associations with certain lifestyle factors on cognitive reserve. Personalized interventions could enhance cognitive resilience in genetically at-risk populations. Comprehensive assessment of multiple lifestyle factors highlights targeted intervention benefits.
Authors
- Rebecca Shakour
- Deirdre M. O’Shea (ORCID: https://orcid.org/0000-0003-3313-7655)
- Lilah M. Besser (ORCID: https://orcid.org/0000-0001-9945-0877)
- James E. Galvin (ORCID: https://orcid.org/0000-0001-5678-245X)
- Andrea S. Zhang
- Katana Rader
Institutions
- University of Miami (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-10-11
- DOI
- https://doi.org/10.1002/alz.14304
- Citations
- 11
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 4.24
Funders
- University of Miami
- National Institutes of Health
- Leonard M. Miller School of Medicine
- National Center for Advancing Translational Sciences