Copper-61 is an advantageous alternative to gallium-68 for PET imaging of somatostatin receptor-expressing tumors: a head-to-head comparative preclinical study
Somatostatin receptor <sup>61</sup>Cu-PET imaging not only matches the performance of <sup>68</sup>Ga-PET at 1 h p.i. but has advantages in late-time imaging at 4 h p.i., as it provides improved tumor-to-non-tumor ratios. [<sup>61</sup>Cu]Cu-NODAGA-TOC is superior to [<sup>61</sup>Cu]Cu-DOTA-TOC <i>in vivo</i>. The use of the chelator NODAGA allows quantitative labeling with copper-61 at room temperature and enables the straightforward use of a kit formulation for simple manufacturing in medical centers.
Authors
- Francesco De Rose
- Raghuvir H. Gaonkar (ORCID: https://orcid.org/0000-0002-9097-7098)
- Tais Basaco Bernabeu
- Anass Johayem
- M. Blagoev
- Melpomeni Fani (ORCID: https://orcid.org/0000-0002-9309-1604)
- Rosalba Mansi (ORCID: https://orcid.org/0000-0003-0342-8865)
- Luigi Del Pozzo
- Lisa McDougall
- Leila Jaafar-Thiel
Institutions
- University of Basel (CH)
- University of Zurich (CH)
- University Hospital of Basel (CH)
- University Hospital of Zurich (CH)
Publication Details
- Journal
- Frontiers in Nuclear Medicine
- Published
- 2024-10-11
- DOI
- https://doi.org/10.3389/fnume.2024.1481343
- Citations
- 1
- Primary Topic
- Neuroendocrine Tumor Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 0.39
Funders
- Innosuisse - Schweizerische Agentur für Innovationsförderung