Amyloid PET detects the deposition of brain Aβ earlier than CSF fluid biomarkers
Amyloid beta (Aβ) positron emission tomography (PET) has greater sensitivity for Aβ deposition than Aβ cerebrospinal fluid (CSF) in early Aβ development. A population-based sample of participants (n = 505) with PET and CSF tests was used. Cortical regions showing early Aβ on Aβ PET were also used in these analyses. Neuropathology was used to validate detection of Aβ by Aβ PET and Aβ CSF biomarkers.
Authors
- Val J. Lowe (ORCID: https://orcid.org/0000-0002-5612-1667)
- Clifford R. Jack (ORCID: https://orcid.org/0000-0001-7916-622X)
- Jonathan Graff‐Radford (ORCID: https://orcid.org/0000-0003-2770-0691)
- Jeyeon Lee (ORCID: https://orcid.org/0000-0002-6168-8385)
- Dennis W. Dickson (ORCID: https://orcid.org/0000-0001-7189-7917)
- Karunya K. Kandimalla (ORCID: https://orcid.org/0000-0001-7786-1915)
- Mary M. Machulda (ORCID: https://orcid.org/0000-0003-4834-5967)
- Alicia Algeciras‐Schimnich (ORCID: https://orcid.org/0000-0002-4455-6217)
- Prashanthi Vemuri (ORCID: https://orcid.org/0000-0003-4286-0589)
- Ronald Carl Petersen (ORCID: https://orcid.org/0000-0002-8178-6601)
- Melissa E. Murray (ORCID: https://orcid.org/0000-0001-7379-2545)
- Matthew L. Senjem (ORCID: https://orcid.org/0000-0001-9308-9275)
- Aivi T. Nguyen (ORCID: https://orcid.org/0000-0003-1809-9451)
- David S. Knopman (ORCID: https://orcid.org/0000-0002-6544-066X)
- Christopher G. Schwarz (ORCID: https://orcid.org/0000-0002-1466-8357)
- David Thomas Jones (ORCID: https://orcid.org/0000-0002-4807-9833)
- Bradley F. Boeve (ORCID: https://orcid.org/0000-0002-4153-8187)
- Emily S. Lundt (ORCID: https://orcid.org/0000-0002-4754-8642)
- Carly Mester (ORCID: https://orcid.org/0000-0002-5863-946X)
- Hoon‐Ki Min (ORCID: https://orcid.org/0000-0002-1084-2469)
- Michelle M. Mielke (ORCID: https://orcid.org/0000-0001-7177-1185)
- Sujala Ghatamaneni
- Michelle R. Campbell (ORCID: https://orcid.org/0000-0002-1472-0194)
- Kejal Kantarci
Institutions
- University of Minnesota (US)
- Mayo Clinic (US)
- Jacksonville College (US)
- WinnMed (US)
- Mayo Clinic in Florida (US)
- Hanyang University (KR)
- Wake Forest University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-10-11
- DOI
- https://doi.org/10.1002/alz.14317
- Citations
- 17
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.55
Funders
- Mayo Clinic
- Mayo Foundation for Medical Education and Research
- GHR Foundation
- Elsie and Marvin Dekelboum Family Foundation
- Schuler-Stiftung
- National Institutes of Health
- Center for Neuroscience Research
- National Institute on Aging