Statin Therapy Reduces Radiation‐Induced Cardiotoxicity in Patients With Breast Cancer Receiving Adjuvant Radiotherapy
Statin therapy is associated with a reduced risk of MACE in patients with breast cancer undergoing breast-conserving surgery and adjuvant whole breast radiotherapy. Hydrophilic statins rosuvastatin and pravastatin exhibit the most pronounced cardioprotective effects. These findings suggest a potential role for statins in mitigating cardiovascular complications in this population and highlight the need for further research to optimize statin therapy in survivors of breast cancer undergoing radiotherapy.
Authors
- Szu‐Yuan Wu (ORCID: https://orcid.org/0000-0001-5637-558X)
- Ben‐Chang Shia (ORCID: https://orcid.org/0000-0003-2854-8361)
- Jui‐An Lin (ORCID: https://orcid.org/0000-0003-0855-4828)
- Wan‐Ming Chen (ORCID: https://orcid.org/0009-0009-6628-0635)
- Yan‐Jiun Huang (ORCID: https://orcid.org/0000-0002-5920-0053)
Institutions
- Fu Jen Catholic University (TW)
- Asia University (TW)
- Luodong Poh-Ai Hospital (TW)
- Taipei Medical University Hospital (TW)
- Chung Shan Medical University Hospital (TW)
- Wan Fang Hospital (TW)
- Taipei Medical University (TW)
- National Defense Medical Center (TW)
- Chung Shan Medical University (TW)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2024-10-11
- DOI
- https://doi.org/10.1161/jaha.124.036411
- Citations
- 16
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 6.43
Funders
- National Science and Technology Council