Association between Immune-Related Adverse Events and Atezolizumab in Previously Treated Patients with Unresectable Advanced or Recurrent Non–Small Cell Lung Cancer
Immune checkpoint inhibitors are useful for treating NSCLC but can cause life-threatening irAEs. This study had a large sample size and stratified the analysis by irAE type and grade. The results suggest that improved management of irAEs may improve the therapeutic effect of atezolizumab.
Authors
- Akihiko Gemma (ORCID: https://orcid.org/0000-0003-0762-2737)
- Takashi Kijima (ORCID: https://orcid.org/0000-0003-4249-4021)
- Toshihiro Misumi (ORCID: https://orcid.org/0000-0001-8339-2895)
- Yasushi Goto (ORCID: https://orcid.org/0000-0002-7437-5054)
- Satoru Miura (ORCID: https://orcid.org/0000-0001-7868-6661)
- Hidetoshi Hayashi (ORCID: https://orcid.org/0000-0001-8787-5587)
- Sadatomo Tasaka (ORCID: https://orcid.org/0000-0003-4861-4143)
- Tetsuro Kondo (ORCID: https://orcid.org/0000-0003-4388-4814)
- Yosuke Kawashima (ORCID: https://orcid.org/0000-0002-9824-6572)
- Shunichiro Iwasawa
- Masaki Fujita (ORCID: https://orcid.org/0000-0003-1209-1272)
- Kei Takamura (ORCID: https://orcid.org/0000-0003-2707-5355)
- Kazuyoshi Imaizumi (ORCID: https://orcid.org/0000-0002-3790-8691)
- Atsuto Mouri (ORCID: https://orcid.org/0000-0001-8704-8151)
- Makoto Nishio (ORCID: https://orcid.org/0000-0003-4969-4165)
- Tetsuya Mitsudomi (ORCID: https://orcid.org/0000-0001-9860-8505)
- Hiroaki Akamatsu (ORCID: https://orcid.org/0000-0001-5856-5512)
- Naoto Takase
- Shintaro Nakagawa
- Ichiro Yoshino (ORCID: https://orcid.org/0009-0003-4007-9606)
Institutions
- Hyogo Medical University (JP)
- Fujita Health University (JP)
- Hirosaki University (JP)
- Chiba University (JP)
- Wakayama Medical University (JP)
- Saitama Prefecture (JP)
- Kanagawa Prefectural Hospital Organization (JP)
- National Cancer Centre Japan (JP)
- National Cancer Center (US)
- Fukuoka University Hospital (JP)
- Niigata Cancer Center Hospital (JP)
- Kindai University Hospital (JP)
- Obihiro Kosei General Hospital (JP)
- Saitama International Medical Center (JP)
- National Cancer Center Hospital East (JP)
- Takarazuka City Hospital (JP)
- Tokyo National Hospital (JP)
- Toa Pharmaceutical (Japan) (JP)
- Sendai Kousei Hospital (JP)
- Japanese Foundation For Cancer Research (JP)
- Kanagawa Cancer Center
- International University of Health and Welfare (JP)
- Nippon Medical School (JP)
- Hyogo University (JP)
- Saitama Medical University (JP)
- Yokohama City University (JP)
- Kindai University (JP)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2024-10-11
- DOI
- https://doi.org/10.1158/2767-9764.crc-24-0212
- Citations
- 2
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- Chugai Pharmaceutical