Functional RNAi Screening Identifies G2/M and Kinetochore Components as Modulators of TNFα/NF-κB Prosurvival Signaling in Head and Neck Squamous Cell Carcinoma
Here, RNAi library screening reveals that multiple G2/M and kinetochore components, including TTK/monopolar spindle 1, modulate TNFα-induced NF-κB activation, cell survival, and genotoxicity, underscoring their potential importance as therapeutic targets in HNSCC.
Authors
- Tiffany Toni (ORCID: https://orcid.org/0000-0003-2119-6914)
- Anastasia L. Sowers (ORCID: https://orcid.org/0000-0002-0841-7068)
- Ethan L. Morgan (ORCID: https://orcid.org/0000-0002-6487-5450)
- Anthony D. Saleh
- Ramya Viswanathan
- Shaleeka Cornelius
- Christopher Silvin
- Pinar Ormanoglu (ORCID: https://orcid.org/0000-0002-2384-8253)
- Scott E. Martin (ORCID: https://orcid.org/0000-0001-5685-9787)
- James B. Mitchell (ORCID: https://orcid.org/0000-0003-1396-6499)
- Paúl E. Clavijo (ORCID: https://orcid.org/0000-0003-2279-2515)
- Carter Van Waes (ORCID: https://orcid.org/0000-0002-9599-5113)
- Sophie G. Carlson
- Zhong Chen (ORCID: https://orcid.org/0000-0002-5322-5110)
- Xinping Yang (ORCID: https://orcid.org/0009-0004-9278-3619)
- Hui Cheng (ORCID: https://orcid.org/0000-0001-5380-2830)
- Jun Jeon
- Madhu Lal-Nag
Institutions
- National Institutes of Health (US)
- University of Sussex (GB)
- National Cancer Institute (US)
- National Center for Advancing Translational Sciences (US)
- Center for Cancer Research (US)
- National Institute on Deafness and Other Communication Disorders (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2024-10-11
- DOI
- https://doi.org/10.1158/2767-9764.crc-24-0274
- Citations
- 3
- Primary Topic
- NF-κB Signaling Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.86
Funders
- Doris Duke Charitable Foundation
- Colgate-Palmolive Company
- American Association for Dental, Oral, and Craniofacial Research
- National Institutes of Health
- Genentech
- National Institute on Deafness and Other Communication Disorders