Neobavaisoflavone Ameliorates Memory Deficits and Brain Damage in Aβ<sub>25‐35</sub>‐Induced Mice by Regulating <scp>SIRT1</scp>
NBIF ameliorated Aβ<sub>25-35</sub>-induced brain injury by inhibiting apoptosis, oxidative stress, and neuroinflammation, which may be mediated through SIRT1 signaling. These findings provide a rationale for NBIF in the treatment of AD and help facilitate the development of clinical therapeutic agents for AD.
Authors
- Xiaoke Zheng (ORCID: https://orcid.org/0000-0003-3671-231X)
- Bing Cao (ORCID: https://orcid.org/0000-0001-5963-2676)
- Mengnan Zeng (ORCID: https://orcid.org/0000-0001-9558-6347)
- Weisheng Feng (ORCID: https://orcid.org/0000-0002-5987-412X)
- Xinmian Jiao
- Fengxiao Hao
- Xiwen Liang
- Kaili Ye
Institutions
- Henan Bioengineering Technology Research Center (CN)
- First Affiliated Hospital of Henan University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1111/cns.70068
- Citations
- 6
- Primary Topic
- Biochemical effects in animals
- Type
- article
- Field-Weighted Citation Impact
- 1.96
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China