Four Core Genotypes mice harbour a 3.2MB X-Y translocation that perturbs Tlr7 dosage
The Four Core Genotypes (FCG) is a mouse model system used to disentangle the function of sex chromosomes and hormones. We report that a copy of a 3.2 MB region of the X chromosome has translocated to the Y<sup>Sry-</sup> chromosome and thus increased the expression of X-linked genes including the single-stranded RNA sensor and autoimmune disease mediator Tlr7. This previously-unreported X-Y translocation complicates the interpretation of studies reliant on C57BL/6J FCG mice.
Authors
- Lauren M. Saunders (ORCID: https://orcid.org/0000-0003-4377-4252)
- Jasper Panten (ORCID: https://orcid.org/0000-0003-4697-7311)
- Moritz Gerstung (ORCID: https://orcid.org/0000-0001-6709-963X)
- Paul A. Ginno (ORCID: https://orcid.org/0000-0002-9864-9427)
- Édith Heard (ORCID: https://orcid.org/0000-0001-8052-7117)
- Job van Riet (ORCID: https://orcid.org/0000-0001-7767-7923)
- James M. A. Turner (ORCID: https://orcid.org/0000-0003-1722-7677)
- Marie-Luise Koch (ORCID: https://orcid.org/0009-0005-9936-6479)
- Arthur P. Arnold (ORCID: https://orcid.org/0000-0002-9908-9767)
- Duncan T. Odom (ORCID: https://orcid.org/0000-0001-6201-5599)
- Xuqi Chen (ORCID: https://orcid.org/0000-0001-7668-9367)
- James Cleland (ORCID: https://orcid.org/0000-0001-8693-1487)
- Anja Schneider (ORCID: https://orcid.org/0009-0004-9225-1145)
- Stefania Prete (ORCID: https://orcid.org/0000-0002-1806-1819)
- Nina Schneider (ORCID: https://orcid.org/0000-0003-0836-5664)
- Oliver Stegle (ORCID: https://orcid.org/0000-0002-8818-7193)
Institutions
- European Molecular Biology Organization (DE)
- University of California, Los Angeles (US)
- German Cancer Research Center (DE)
- Collège de France (FR)
- Heidelberg University (DE)
- The Francis Crick Institute (GB)
- European Molecular Biology Laboratory (DE)
- European Molecular Biology Laboratory (DE)
Publication Details
- Journal
- Nature Communications
- Published
- 2024-10-11
- DOI
- https://doi.org/10.1038/s41467-024-52640-8
- Citations
- 28
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 6.73
Funders
- Deutsches Krebsforschungszentrum
- Bundesministerium für Bildung und Forschung
- National Institutes of Health