From Gut to Blood: Redistribution of Zonulin in People Living with HIV
The findings of this study indicate a shift in zonulin levels from the gut to the bloodstream in response to HIV infection. Furthermore, elevated systemic zonulin levels are associated with the depletion of intestinal CD4<sup>+</sup> T cells and increased gut inflammation, suggesting a potential link between systemic zonulin and intestinal damage. Gaining insight into the regulation of gut tight junctions during HIV infection could offer valuable understanding for preventing NICM in PLWH.
Authors
- Elena Knops (ORCID: https://orcid.org/0000-0001-7398-3026)
- Darragh Duffy (ORCID: https://orcid.org/0000-0002-8875-2308)
- Eva Heger (ORCID: https://orcid.org/0000-0001-7625-5139)
- Ute Sandaradura de Silva
- Dirk Nierhoff (ORCID: https://orcid.org/0000-0001-7297-2675)
- Christoph Wenisch
- Max Augustin (ORCID: https://orcid.org/0000-0002-2300-9337)
- Clara Lehmann (ORCID: https://orcid.org/0000-0002-7042-1578)
- Vincent Bondet (ORCID: https://orcid.org/0000-0002-6534-0984)
- Michaela Müller‐Trutwin (ORCID: https://orcid.org/0000-0002-3854-2396)
- Seung‐Hun Chon (ORCID: https://orcid.org/0000-0002-8923-6428)
- Isabelle Suárez (ORCID: https://orcid.org/0000-0002-9863-9675)
- Florian Klein (ORCID: https://orcid.org/0000-0003-1376-1792)
- Meryem S. Ercanoglu (ORCID: https://orcid.org/0000-0001-8026-8565)
- Carola Horn (ORCID: https://orcid.org/0000-0002-8026-6495)
- Alexander Zoufaly
Institutions
- Sigmund Freud Privatuniversität Wien (AT)
- Institut Pasteur (FR)
- University of Cologne (DE)
- Université Paris Cité (FR)
- German Center for Infection Research (DE)
- University Hospital Cologne (DE)
Publication Details
- Journal
- Biomedicines
- Published
- 2024-10-11
- DOI
- https://doi.org/10.3390/biomedicines12102316
- Citations
- 4
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- Deutsches Zentrum für Infektionsforschung