Glial Cell Responses and Gene Expression Dynamics in Retinas of Treated and Untreated <i>RPE65</i> Mutant Dogs
Gene expression data suggest a shift from pro-degenerative mechanisms in middle-aged mutant retinas to more compensatory mechanisms in preserved retinal regions at advanced stages, despite ongoing degeneration. Such shift, potentially attributed to a number of surviving resilient cells, may influence disease patterns and treatment outcomes.
Authors
- William A. Beltran (ORCID: https://orcid.org/0000-0002-1127-4774)
- Geoffrey K. Aguirre (ORCID: https://orcid.org/0000-0002-4028-3100)
- Evelyn Santana (ORCID: https://orcid.org/0009-0008-7904-0932)
- Tatyana Appelbaum (ORCID: https://orcid.org/0000-0001-8765-4792)
- David A. Smith (ORCID: https://orcid.org/0000-0001-8668-5319)
Institutions
- University of Pennsylvania (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2024-10-11
- DOI
- https://doi.org/10.1167/iovs.65.12.18
- Citations
- 3
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- National Institutes of Health