Inconsistency in ferritin reference intervals across laboratories: a major concern for clinical decision making
The lack of harmonization in ferritin measurement and the disagreement in plasma ferritin reference intervals significantly impact the interpretation of the iron status of patients and thereby the number of iron disorder diagnoses made. Standardization or harmonization of the ferritin assays and establishing uniform reference intervals and medical decision limits are essential to reduce the substantial variability in clinical interpretations of ferritin results.
Authors
- A. de Jong
- Steef Kurstjens (ORCID: https://orcid.org/0009-0008-4409-5079)
- Johannes G. Krabbe (ORCID: https://orcid.org/0000-0003-1585-9304)
- Marieke A. M. Frasa
- Wendy P. J. den Elzen (ORCID: https://orcid.org/0000-0002-6774-4077)
- Maarten B. Kok (ORCID: https://orcid.org/0000-0002-7038-4244)
- Firmin Candido (ORCID: https://orcid.org/0000-0002-5060-5644)
- Ron Kusters
- Yvo F.C. Kortmann
- Ron M. C. Herings (ORCID: https://orcid.org/0000-0002-2561-8734)
- Andrea D. van Dam
- Ellis Oortwijn
- B. Boer
- Anoeska Schipper
Institutions
- Radboud University Nijmegen (NL)
- Medisch Spectrum Twente (NL)
- Radboud University Medical Center (NL)
- Alrijne Ziekenhuis (NL)
- Canisius-Wilhelmina Ziekenhuis (NL)
- Pharmo Institute (NL)
- GGD Amsterdam (NL)
- Elisabeth-TweeSteden Ziekenhuis (NL)
- Amsterdam University Medical Centers (NL)
- Jeroen Bosch Ziekenhuis (NL)
- Vrije Universiteit Amsterdam (NL)
- University of Amsterdam (NL)
- University of Twente (NL)
Publication Details
- Journal
- Clinical Chemistry and Laboratory Medicine (CCLM)
- Published
- 2024-10-11
- DOI
- https://doi.org/10.1515/cclm-2024-0826
- Citations
- 6
- Primary Topic
- Iron Metabolism and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.73