Microglial priming by <scp>IFN</scp>‐γ involves <scp>STAT1</scp>‐mediated activation of the <scp>NLRP3</scp> inflammasome
IFN-γ primes microglia by activating STAT1, which upregulates genes that activate the NLRP3 inflammasome. Inhibiting the IFN-γ/STAT1 axis may be a way to treat neurodegenerative diseases and psychiatric disorders that involve microglial priming.
Authors
- Zili You (ORCID: https://orcid.org/0000-0002-7776-6229)
- Yue Liu (ORCID: https://orcid.org/0000-0001-8042-1443)
- Liangyuan Li (ORCID: https://orcid.org/0000-0003-2862-2525)
- Haili He
- Xiaomei Zhang (ORCID: https://orcid.org/0000-0002-7500-7317)
- Jinqiang Zhang (ORCID: https://orcid.org/0000-0003-1563-827X)
- Hui He (ORCID: https://orcid.org/0000-0003-1915-7756)
- Chengyan Yang (ORCID: https://orcid.org/0009-0008-2479-5502)
- Gaojie Xu
Institutions
- Guiyang College of Traditional Chinese Medicine (CN)
- University of Electronic Science and Technology of China (CN)
- Guizhou University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1111/cns.70061
- Citations
- 23
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 5.38