Alterations in the Renin-Angiotensin System in Experimental Septic Shock
The study highlighted dynamic shifts in the RAS during septic shock, characterized by reduced circulating ACE activity, elevated angiotensin I/II ratio, and a shift toward the angiotensin-(1-7) axis. These findings suggest an adaptive response within the RAS, potentially offering new insights into sepsis management and therapeutic targets.
Authors
- Fabio Silvio Taccone (ORCID: https://orcid.org/0000-0003-0830-1628)
- Raphaël Favory (ORCID: https://orcid.org/0000-0001-7772-2608)
- Antoine Herpain (ORCID: https://orcid.org/0000-0002-0981-0208)
- Adrien Picod (ORCID: https://orcid.org/0000-0002-0639-5598)
- Jacques Créteur (ORCID: https://orcid.org/0000-0003-1405-7852)
- Fuhong Su (ORCID: https://orcid.org/0000-0003-4962-7907)
- Alexandre Mebazaa (ORCID: https://orcid.org/0000-0001-8715-7753)
- Bruno Garcia (ORCID: https://orcid.org/0000-0001-6650-1594)
- Filippo Annoni (ORCID: https://orcid.org/0000-0002-1271-9034)
- Benoit Ter Schiphorst
- Theo Ikenna-Uba
- Jean-Louis Vincent
Institutions
- Université Libre de Bruxelles (BE)
- Inserm (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Lariboisière (FR)
- Paris Cardiovascular Research Center (FR)
Publication Details
- Journal
- Critical Care Explorations
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1097/cce.0000000000001163
- Citations
- 2
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.77