Novel therapeutic strategy for intractable keloids: suppression of intracellular mechanotransduction and actin polymerization via Rho-kinase pathway inhibition
The ROCK1 inhibitor Y27632 is a promising molecule for keloid treatment, exerting its effects through actin cytoskeleton remodelling and nuclear inhibition of fibrotic markers in keloid pathogenesis.
Authors
- Ji‐Ung Park (ORCID: https://orcid.org/0000-0002-6403-4918)
- Ki‐Myo Kim
- Mi Hyun Lee (ORCID: https://orcid.org/0000-0001-9747-2888)
- Sally Min (ORCID: https://orcid.org/0000-0002-7750-6590)
- Jun Ho Park (ORCID: https://orcid.org/0000-0003-0235-1261)
- Joseph Hwang
Institutions
- Seoul National University (KR)
- New Generation University College (ET)
- National University College (PR)
Publication Details
- Journal
- British Journal of Dermatology
- Published
- 2024-10-11
- DOI
- https://doi.org/10.1093/bjd/ljae384
- Citations
- 5
- Primary Topic
- Dermatologic Treatments and Research
- Type
- article
- Field-Weighted Citation Impact
- 2.67