High Prevalence of Carbapenem-resistant <i>Klebsiella Pneumoniae</i> in Fecal and Water Samples in Dhaka, Bangladesh
We evaluated <i>Klebsiella pneumoniae</i> (Kp) gut carriage in healthy, unrelated adults and children living in separate households in Dhaka, Bangladesh. Average Kp prevalence in stool samples ranged from 61% in young children (15/25) to 81% in adults (21/26), with significantly higher abundance in adults (<i>P</i> = .03, <i>t</i>-test). Kp was also prevalent in household water (64%, 21/33) and standing water (85%, 23/27). The presence of Kp in household water was not strongly linked to stool Kp abundance among household members. Antimicrobial resistance was notable: 9% (6/69) of stool and 16% (7/44) of water isolates exhibited multidrug resistance. Carbapenem resistance was observed in 12% of stool isolates (8/69) and 14% of water isolates (6/44). These findings underscore the commonality of Kp in human and environmental reservoirs in Dhaka, Bangladesh, and highlight the emergence of drug-resistant Kp beyond healthcare settings.
Authors
- Colin J. Worby (ORCID: https://orcid.org/0000-0002-9132-7249)
- Mohammad Tanbir Habib (ORCID: https://orcid.org/0000-0001-6828-9283)
- Firdausi Qadri (ORCID: https://orcid.org/0000-0001-8459-304X)
- Nusrat Noor Tanni (ORCID: https://orcid.org/0000-0001-7509-0424)
- SM Shamsuzzaman (ORCID: https://orcid.org/0000-0003-2886-8840)
- Damien Slater (ORCID: https://orcid.org/0000-0002-1115-0894)
- Kasrina Azad
- Regina C. LaRocque (ORCID: https://orcid.org/0000-0003-4558-0339)
- Zannat Kawser (ORCID: https://orcid.org/0000-0001-7628-137X)
- Sushmita Sridhar
- Ashlee M. Earl (ORCID: https://orcid.org/0000-0001-7857-9145)
- Jason B. Harris (ORCID: https://orcid.org/0000-0003-3642-5126)
- Sanchita Kar (ORCID: https://orcid.org/0000-0003-1098-8449)
- Abu Bakar Siddik (ORCID: https://orcid.org/0000-0002-5027-4902)
- Meherunnisa Moonmoon
- Sharmin Aktar Mukta (ORCID: https://orcid.org/0009-0006-8608-8753)
- Raisa Tasnia Khan
- Neamul Hasan
Institutions
- Broad Institute (US)
- Harvard University (US)
- Bangladesh Institute of Development Studies (BD)
- International Centre for Diarrhoeal Disease Research (BD)
- Massachusetts General Hospital (US)
- Development Initiatives (GB)
- Dhaka Medical College and Hospital (BD)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2024-10-11
- DOI
- https://doi.org/10.1093/ofid/ofae612
- Citations
- 2
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.34
Funders
- Massachusetts General Hospital
- National Institutes of Health