Pilot Randomized Clinical Trial of a Passive Non-invasive Positive End-Expiratory Pressure (PEEP) Device for Delivering Positive Pressure Therapy Compared to Standard Care in Non-critically Ill Patients With COVID-19
The use of the novel mask compared to standard care in hospitalized non-critically ill patients with COVID-19 was not associated with reductions in the respiratory rate but was associated with a reduction in the need for escalation of respiratory support without an increase in adverse effects. Large-scale clinical trials of this device are warranted.
Authors
- Serena Knowles (ORCID: https://orcid.org/0000-0002-5028-3825)
- Nikita Bathla (ORCID: https://orcid.org/0000-0001-8828-5036)
- Sheila Nainan Myatra (ORCID: https://orcid.org/0000-0001-6761-163X)
- Senthilkumar Rajagopal (ORCID: https://orcid.org/0000-0002-8404-8209)
- Abhinav Bassi (ORCID: https://orcid.org/0000-0003-0750-9179)
- Bharath Kumar Tirupakuzhi Vijayaraghavan (ORCID: https://orcid.org/0000-0002-1801-0667)
- Vivekanand Jha (ORCID: https://orcid.org/0000-0002-8015-9470)
- Kirti N Saxena (ORCID: https://orcid.org/0000-0002-2045-243X)
- Lovenish Bains (ORCID: https://orcid.org/0000-0002-8627-0452)
- Gian Luca Di Tanna (ORCID: https://orcid.org/0000-0002-5470-3567)
- Naomi E. Hammond (ORCID: https://orcid.org/0000-0002-6559-7747)
- Lalit Gupta (ORCID: https://orcid.org/0000-0001-7291-5961)
- Xiaoqiu Liu (ORCID: https://orcid.org/0000-0002-8320-2075)
- Balasubramanian Venkatesh (ORCID: https://orcid.org/0000-0003-2893-6954)
- Jigeeshu Vasishtha Divatia
Institutions
- The University of Sydney (AU)
- Apollo Hospitals (IN)
- The University of Queensland (AU)
- The George Institute for Global Health (GB)
- Royal North Shore Hospital (AU)
- Tata Memorial Hospital (IN)
- Wesley Hospital (AU)
- UNSW Sydney (AU)
- Maulana Azad Medical College (IN)
- Lok Nayak Jai Prakash Narayan Hospital (IN)
- The George Institute for Global Health (AU)
- Apollo Hospitals (IN)
- George Institute for Global Health (IN)
- Princess Alexandra Hospital (GB)
- George Institute for Global Health (CN)
- Apollo Hospitals (IN)
- Imperial College London (GB)
Publication Details
- Journal
- Cureus
- Published
- 2024-10-11
- DOI
- https://doi.org/10.7759/cureus.71267
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00