Immune microenvironment modulation following neoadjuvant therapy for oesophageal adenocarcinoma: a translational analysis of the DEBIOC clinical trial
OAC may be subdivided into three immune-related subgroups which undergo modulation in response to neoadjuvant therapy with marked suppression of the immune microenvironment in HER2-positive/immune-high tumours.
Authors
- Stephanie G. Craig (ORCID: https://orcid.org/0000-0002-5476-751X)
- Sandra Van Schaeybroeck (ORCID: https://orcid.org/0000-0002-8853-1388)
- Julie Turbitt
- Leena Elhussein (ORCID: https://orcid.org/0000-0001-7908-1912)
- Richard Calvin Turkington (ORCID: https://orcid.org/0000-0003-3164-1890)
- Jaine K. Blayney (ORCID: https://orcid.org/0000-0001-5618-5284)
- Enya Scanlon (ORCID: https://orcid.org/0000-0002-1952-511X)
- Russell Petty (ORCID: https://orcid.org/0000-0003-2055-4572)
- Stephen McQuaid (ORCID: https://orcid.org/0000-0003-0794-8569)
- Z Miedzybrodzka
- Mark R. Middleton (ORCID: https://orcid.org/0000-0003-0167-1685)
- Ryan M. Byrne (ORCID: https://orcid.org/0000-0001-6505-6345)
- Jacqueline A. James
- Pradeep S. Virdee (ORCID: https://orcid.org/0000-0002-3006-8730)
- Adrian Lavery
- Anne Thomas (ORCID: https://orcid.org/0000-0003-1998-3134)
- David Collinson (ORCID: https://orcid.org/0000-0002-0884-9960)
- Richard D. Kennedy (ORCID: https://orcid.org/0000-0003-4737-6163)
- D. Paul Harkin
- Leanne Stevenson
- Mohammad Albraikat
- B Mullan-Young
- A. Walker
- Damian McManus
- Cameron Kennedy
- Martin Eatock
Institutions
- Queen's University Belfast (GB)
- Belfast Health and Social Care Trust (GB)
- University of Leicester (GB)
- University of Aberdeen (GB)
- Ninewells Hospital (GB)
- University of Oxford (GB)
Publication Details
- Journal
- ESMO Open
- Published
- 2024-10-11
- DOI
- https://doi.org/10.1016/j.esmoop.2024.103930
- Primary Topic
- Esophageal Cancer Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- AstraZeneca
- Health Research Board
- Friends of the Cancer Centre
- Cancer Research UK
- National Institute for Health and Care Research
- Department of Health and Social Care
- Public Health Agency
- Imperial Experimental Cancer Medicine Centre