High glycemic variability is associated with a reduced T cell cytokine response to influenza A virus
Diabetes mellitus significantly increases the risk of severe respiratory virus disease like influenza and COVID-19. Early evidence suggests that this susceptibility to respiratory viral disease is driven by glycemic variability, rather than average blood glucose levels. Here, we use blood samples and constant glucose monitoring (CGM) data obtained from people living with type 1 diabetes (T1D) to determine the effects of glycemic variability on the <i>ex vivo</i> T cell response to influenza virus. We show that high glycemic variability in participants living with T1D is associated with a reduced proportion of CD8<sup>+</sup>CD107a<sup>-</sup>IFNγ<sup>-</sup>MIP1β<sup>-</sup>TNF<sup>+</sup> T cells in response to stimulation with influenza virus and an influenza virus peptide pool. Thus, this study provides evidence that glycemic variability affects the <i>ex vivo</i> T cell response to respiratory viruses. These data suggest that monitoring glycemic variability may have important implications in understanding the antiviral immune response in people with diabetes.
Authors
- Katherine Kedzierska (ORCID: https://orcid.org/0000-0001-6141-335X)
- Katina D. Hulme (ORCID: https://orcid.org/0000-0003-1322-0136)
- Ellesandra C. Noye (ORCID: https://orcid.org/0000-0003-1300-5129)
- Corey Smith (ORCID: https://orcid.org/0000-0002-7550-9595)
- Soi Cheng Law
- Marcus Z. W. Tong
- Kirsty R. Short (ORCID: https://orcid.org/0000-0003-4963-6184)
- Emma J. Grant (ORCID: https://orcid.org/0000-0001-7193-9427)
- Jean‐Baptiste Julla (ORCID: https://orcid.org/0000-0002-4497-5710)
- Katie E. Lineburg (ORCID: https://orcid.org/0000-0002-5712-2610)
- Jean‐Pierre Riveline (ORCID: https://orcid.org/0000-0001-7991-0741)
- Katharina Ronacher (ORCID: https://orcid.org/0000-0002-6371-1462)
- Fawaz Alzaïd (ORCID: https://orcid.org/0000-0003-3056-3640)
- Louise C. Rowntree (ORCID: https://orcid.org/0000-0002-0649-5089)
- Marco Goeijenbier (ORCID: https://orcid.org/0000-0002-3165-8193)
- Carolien E. van de Sandt (ORCID: https://orcid.org/0000-0002-4155-7433)
- Helen L. Barrett (ORCID: https://orcid.org/0000-0001-7141-2086)
- Linda A. Gallo (ORCID: https://orcid.org/0000-0002-0471-8517)
- Stéphanie Gras (ORCID: https://orcid.org/0000-0001-7416-038X)
- Emily S. Dorey (ORCID: https://orcid.org/0009-0002-7906-1967)
- Keng Yih Chew
Institutions
- Centre National de la Recherche Scientifique (FR)
- Translational Research Institute (AU)
- Inserm (FR)
- The University of Queensland (AU)
- The University of Melbourne (AU)
- University of the Sunshine Coast (AU)
- La Trobe University (AU)
- Université Paris Cité (FR)
- QIMR Berghofer Medical Research Institute (AU)
- Royal Hospital for Women (AU)
- Australian Regenerative Medicine Institute (AU)
- Erasmus MC (NL)
- Amsterdam UMC Location University of Amsterdam (NL)
- Sanquin (NL)
- UNSW Sydney (AU)
- Institut Necker Enfants Malades (FR)
- Mater Research (AU)
- Spaarne Ziekenhuis (NL)
- Peter Doherty Institute (AU)
- Hôpital Lariboisière (FR)
- Amsterdam University Medical Centers (NL)
- Dasman Diabetes Institute (KW)
- University of Amsterdam (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- iScience
- Published
- 2024-10-11
- DOI
- https://doi.org/10.1016/j.isci.2024.111166
- Citations
- 2
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.10
Funders
- University of Melbourne
- Medical Research Council
- Australian Research Council
- National Health and Medical Research Council