Heightened mitochondrial respiration in CF cells is normalised by triple CFTR modulator therapy through mechanisms involving calcium
CF cell lines exhibit increased mitochondrial respiration, which can be downregulated by ETI therapy through mechanisms involving calcium.
Authors
- Sinisa Savic (ORCID: https://orcid.org/0000-0001-7910-0554)
- Heledd Jarosz-Griffiths (ORCID: https://orcid.org/0000-0001-5154-4815)
- D. Peckham (ORCID: https://orcid.org/0000-0001-7723-1868)
- M.F. McDermott
- Samuel Lara‐Reyna (ORCID: https://orcid.org/0000-0002-9986-5279)
- I. Clifton (ORCID: https://orcid.org/0000-0002-9758-9506)
- L.R. Caley (ORCID: https://orcid.org/0000-0001-8957-1018)
Institutions
- University of Leeds (GB)
- Leeds Teaching Hospitals NHS Trust (GB)
- St James's University Hospital (GB)
- NIHR Leeds Musculoskeletal Biomedical Research Unit (GB)
- University of Birmingham (GB)
Publication Details
- Journal
- Heliyon
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e39244
- Citations
- 6
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- Leeds Hospital Charitable Foundation
- Cystic Fibrosis Trust