From fetus to 8: the CHILD Cohort Study
The CHILD Cohort Study is an active multi-center longitudinal, prospective, population pregnancy cohort study following Canadian infants from fetal life until adulthood. We hypothesized that early life physical and psychosocial environments interact with biological factors (e.g. immunologic, genetic, physiologic, and metabolic) influencing burdensome non-communicable disease outcomes, including asthma and allergic disorders, growth and development, cardio-metabolic health, and neurodevelopmental outcomes that manifest during the life-course. Detailed clinical and physiologic phenotyping at strategic intervals was complemented by environmental sampling, actigraphy and global positioning system measures, biological sampling including gut, breastmilk and nasal microbiome, nutritional studies, genetics, and epigenetic profiling. Of 3,454 families recruited from 2008 to 2012, study retention was 96.0% at 1-year, 93.2% at 5-years and 90.7% at 8-years. Data collection during the SARS-2 COVID-19 pandemic was partially completed via virtual visits. A sub-cohort was implemented, capturing detailed information on the prevalence and predictors of SARS-CoV-2 infection and the health and psychosocial impact of the pandemic on Canadian families. The 13-year clinical assessment launched in 2022 will be completed in 2025. Ultimately, the CHILD Cohort Study provides a data science platform designed to enable a deep understanding of early life factors associated with the development of chronic non-communicable diseases and multimorbidity.
Authors
- Jeffrey R. Brook (ORCID: https://orcid.org/0000-0002-4165-2190)
- Malcolm R. Sears (ORCID: https://orcid.org/0000-0002-7113-4917)
- Allan B. Becker (ORCID: https://orcid.org/0000-0002-4707-8177)
- Wendy Lou (ORCID: https://orcid.org/0000-0001-5590-8719)
- Ruixue Dai (ORCID: https://orcid.org/0000-0001-5485-2725)
- Qing Duan (ORCID: https://orcid.org/0000-0003-4467-7024)
- Meghan B. Azad (ORCID: https://orcid.org/0000-0002-5942-4444)
- Theo J. Moraes (ORCID: https://orcid.org/0000-0001-9968-6601)
- Piush J. Mandhane (ORCID: https://orcid.org/0000-0003-3682-9120)
- Justin Cook (ORCID: https://orcid.org/0000-0003-3457-2552)
- Myrtha E. Reyna (ORCID: https://orcid.org/0000-0002-1790-1724)
- Bassel Dawod (ORCID: https://orcid.org/0000-0002-1055-4387)
- Stuart E. Turvey (ORCID: https://orcid.org/0000-0003-1599-1065)
- Fiona S. L. Brinkman (ORCID: https://orcid.org/0000-0002-0584-4099)
- Padmaja Subbarao (ORCID: https://orcid.org/0000-0003-0394-1933)
- Geoffrey L. Winsor (ORCID: https://orcid.org/0000-0001-6848-1638)
- Kozeta Miliku (ORCID: https://orcid.org/0000-0002-9614-7191)
- Aimée Dubeau (ORCID: https://orcid.org/0000-0002-8762-4240)
- Diana L. Lefebvre (ORCID: https://orcid.org/0000-0003-4186-5521)
- Michael Steffen Kobor (ORCID: https://orcid.org/0000-0003-4140-1743)
- Maria Medeleanu (ORCID: https://orcid.org/0000-0002-7249-8093)
- Marshall Beck
- Kim Wright (ORCID: https://orcid.org/0000-0002-1164-3074)
- Elinor Simons
- Elissa Brooks
Institutions
- Manitoba Health (CA)
- University of British Columbia (CA)
- University of Alberta (CA)
- Simon Fraser University (CA)
- University of Toronto (CA)
- Queen's University (CA)
- Hospital for Sick Children (CA)
- Public Health Ontario (CA)
- SickKids Foundation (CA)
- BC Children's Hospital (CA)
- University of Manitoba (CA)
- Hamilton Health Sciences (CA)
- McMaster University (CA)
Publication Details
- Journal
- American Journal of Epidemiology
- Published
- 2024-10-11
- DOI
- https://doi.org/10.1093/aje/kwae397
- Citations
- 9
- Primary Topic
- Child and Adolescent Health
- Type
- article
- Field-Weighted Citation Impact
- 7.64
Funders
- Children's Health Research Institute
- Genome Canada
- McMaster University
- Women and Children's Health Research Institute
- Children's Hospital Foundation
- BC Children's Hospital
- Compute Canada
- University of Alberta
- Genome British Columbia
- Provincial Health Services Authority
- University of Toronto
- Simon Fraser University
- Genome Alberta
- Canadian Institutes of Health Research