Mechanisms and consequences of myeloid adhesome dysfunction in atherogenesis
This study shows that the loss of Kindlin3 in macrophages upon exposure to oxLDL leads to adhesome dysfunction in atherosclerosis and reveals the pivotal role of Kindlin3 in macrophage function and its contribution to the progression of atherosclerosis, providing valuable insights into the molecular mechanisms that could be targeted for therapeutic interventions.
Authors
- Svyatoslav Tkachenko (ORCID: https://orcid.org/0000-0001-8687-1576)
- Irina Zhevlakova (ORCID: https://orcid.org/0000-0002-8596-3329)
- Tatiana V. Byzova (ORCID: https://orcid.org/0000-0002-2615-875X)
- Tejasvi Dudiki (ORCID: https://orcid.org/0000-0002-2844-1946)
- Detao Gao (ORCID: https://orcid.org/0000-0002-3002-9934)
- Eugene A. Podrez (ORCID: https://orcid.org/0000-0002-9550-6965)
- Valentin P. Yakubenko (ORCID: https://orcid.org/0000-0002-0242-3061)
- Huan Liu (ORCID: https://orcid.org/0000-0002-2676-6982)
- Olga A. Cherepanova (ORCID: https://orcid.org/0000-0003-0045-8102)
Institutions
- East Tennessee State University (US)
- Cleveland Clinic (US)
- Cleveland Clinic Lerner College of Medicine (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2024-10-12
- DOI
- https://doi.org/10.1093/cvr/cvae223
- Citations
- 5
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 1.91
Funders
- National Institutes of Health