Fangchinoline suppresses hepatocellular carcinoma by regulating ROS accumulation via the TRIM7/Nrf2 signaling pathway
The study determines the anti-liver cancer effect of FAN and first describes the positive regulatory effect of TRIM7 on Nrf2 signaling. We reveal that TRIM7/Nrf2 signaling served as a target of FAN-induced ROS accumulation in HCC, which helps to clarify the mechanism of action of FAN against HCC and provides a theoretical basis for FAN as an anti-cancer drug.
Authors
- Mingxi Gan
- Luoting Chen (ORCID: https://orcid.org/0000-0002-9425-476X)
- Tianyu Han (ORCID: https://orcid.org/0000-0002-1471-611X)
- Jianbin Wang (ORCID: https://orcid.org/0000-0001-6725-7925)
- Xingxing Wang (ORCID: https://orcid.org/0000-0003-4437-5229)
- Yange Liu (ORCID: https://orcid.org/0000-0003-3428-5692)
- Ya‐Wen Wang
- Hang Lian
- Juan Wang (ORCID: https://orcid.org/0000-0001-9452-7900)
Institutions
- Liaoning University (CN)
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- First Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2024-10-11
- DOI
- https://doi.org/10.1016/j.phymed.2024.156143
- Citations
- 13
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- National Natural Science Foundation of China