NAT10 resolves harmful nucleolar R-loops depending on its helicase domain and acetylation of DDX21
We demonstrate that NAT10 is a novel R-loop resolvase and it resolves nucleolar R-loops depending on its helicase activity and acetylation of DDX21. The cooperation of NAT10 and DDX21 provides comprehensive insights into the nucleolar R-loop resolution for maintaining genome stability.
Authors
- Zhuochen Zhao (ORCID: https://orcid.org/0000-0001-9187-0199)
- Xiaojuan Du (ORCID: https://orcid.org/0000-0002-0108-511X)
- Shiqi Sun (ORCID: https://orcid.org/0009-0009-7257-7996)
- Yang Jiang (ORCID: https://orcid.org/0000-0001-9066-9418)
- Kunqi Su (ORCID: https://orcid.org/0000-0003-3086-4312)
- Xiaofeng Liu (ORCID: https://orcid.org/0000-0002-3264-122X)
- Chunfeng Zhang (ORCID: https://orcid.org/0000-0002-0402-2683)
- Yuying Wang (ORCID: https://orcid.org/0009-0003-3740-8472)
Institutions
- Peking University (CN)
- Peking University Cancer Hospital (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2024-10-11
- DOI
- https://doi.org/10.1186/s12964-024-01869-3
- Citations
- 8
- Primary Topic
- DNA Repair Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China
- Beijing Municipal Natural Science Foundation