5-Hydroxymethylated Biomarkers in Cell-Free DNA Predict Occult Colorectal Cancer up to 36 Months Before Diagnosis in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
Candidate 5hmC biomarkers and a scoring algorithm have the potential to predict CRC occurrence despite the absence of clinical symptoms and effective predictors. Developing a minimally invasive clinical assay that detects 5hmC-modified biomarkers holds promise for improving early CRC detection and ultimately patient outcomes.
Authors
- Xiaolong Cui (ORCID: https://orcid.org/0000-0002-1345-2271)
- Marc Bissonnette (ORCID: https://orcid.org/0000-0001-8420-4294)
- Shannon Merkle (ORCID: https://orcid.org/0000-0003-0848-3628)
- Krissana Kowitwanich
- Craig Williams (ORCID: https://orcid.org/0000-0002-4758-1506)
- Chuan He (ORCID: https://orcid.org/0000-0002-9983-7526)
- Diana C. West-Szymanski (ORCID: https://orcid.org/0000-0002-2933-1159)
- Urszula Dougherty
- Zhou Zhang (ORCID: https://orcid.org/0000-0001-9525-6938)
- Wei Zhang (ORCID: https://orcid.org/0000-0003-0875-263X)
- Zifeng Deng
- Lu Gao (ORCID: https://orcid.org/0009-0006-3950-9332)
Institutions
- Northwestern University (US)
- Howard Hughes Medical Institute (US)
- University of Chicago (US)
- Information Management Services (US)
Publication Details
- Journal
- JCO Precision Oncology
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1200/po.24.00277
- Citations
- 4
- Primary Topic
- Colorectal Cancer Screening and Detection
- Type
- article
- Field-Weighted Citation Impact
- 1.13
Funders
- National Cancer Institute