Poly (ADP-ribose) Polymerase Inhibitor Resistance Driven by Emergence of Polyclonal Mutations With Convergent Evolution: A Molecular Tumor Board Discussion
Polyclonal convergent evolution to PARPi resistance in a patient with metastatic breast cancer with gPALB2.
Authors
- David Kamson (ORCID: https://orcid.org/0000-0002-0473-658X)
- Faith Too
- Archana Balan (ORCID: https://orcid.org/0000-0003-1283-577X)
- Antonio C. Wolff (ORCID: https://orcid.org/0000-0003-3734-1063)
- Christopher D. Gocke (ORCID: https://orcid.org/0000-0002-9541-2192)
- Kory Kreimeyer (ORCID: https://orcid.org/0000-0002-5434-1420)
- Rachel Karchin (ORCID: https://orcid.org/0000-0002-5069-1239)
- Cesar A. Santa‐Maria (ORCID: https://orcid.org/0000-0003-0979-8787)
- Jonathan Spiker
- Jennifer Lehman (ORCID: https://orcid.org/0000-0001-7114-208X)
- Paola Ghanem (ORCID: https://orcid.org/0000-0001-8134-665X)
- Michael Conroy (ORCID: https://orcid.org/0000-0001-9048-5213)
- Mohammad A. Alzubi (ORCID: https://orcid.org/0000-0002-8788-5440)
- Laura Linville (ORCID: https://orcid.org/0000-0001-6993-3421)
- Valsamo Anagnostou (ORCID: https://orcid.org/0000-0001-9480-3047)
- Vered Stearns (ORCID: https://orcid.org/0000-0003-4018-4708)
- Rima Couzi
- Karisa C. Schreck (ORCID: https://orcid.org/0000-0001-7181-3269)
- John Laterra (ORCID: https://orcid.org/0000-0002-2983-5365)
- Taxiarchis Botsis (ORCID: https://orcid.org/0000-0001-7848-2570)
- Jenna VanLiere Canzoniero (ORCID: https://orcid.org/0000-0003-1084-6918)
- Dana Petry (ORCID: https://orcid.org/0000-0002-0546-3325)
- Christine A. Pratilas (ORCID: https://orcid.org/0000-0002-7116-0605)
- Jessica J. Tao (ORCID: https://orcid.org/0000-0002-6532-4466)
- Christian F. Meyer (ORCID: https://orcid.org/0000-0003-3329-7106)
- Rena R. Xian (ORCID: https://orcid.org/0000-0001-5532-6524)
- Kala Visvanathan (ORCID: https://orcid.org/0000-0002-0582-8005)
- Deborah K. Armstrong (ORCID: https://orcid.org/0000-0003-0852-803X)
- Timsy Wanchoo
- Katerina Karaindrou
- Ying Zou (ORCID: https://orcid.org/0000-0002-6166-9854)
- Ming‐Tseh Lin (ORCID: https://orcid.org/0000-0002-8446-7817)
- Mohamed Sherief
- Monique Makell
- Maria Durham
- Ting He
- Mimi Najjar (ORCID: https://orcid.org/0009-0007-4609-2157)
- Jaime Wehr
- Maria Fatteh
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
Publication Details
- Journal
- JCO Precision Oncology
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1200/po.24.00254
- Citations
- 5
- Primary Topic
- PARP inhibition in cancer therapy
- Type
- article
- Field-Weighted Citation Impact
- 1.41
Funders
- Bristol-Myers Squibb
- AstraZeneca
- Instituto Tecnológico de Costa Rica
- National Institutes of Health
- Foundation Medicine