Pediatric MOG-Ab–Associated Encephalitis
MOG-Ab should be tested in all patients with suspected encephalitis even in the context of initially normal brain MRI. Although exclusion of infections should be part of the diagnostic process of any child with encephalitis, in immunocompetent children, when herpes simplex virus CSF PCR and gram stains are negative, these features do not preclude the diagnosis of immune mediated disease and should not delay initiation of first-line immunosuppression (steroids, IVIG, plasma exchange), even while awaiting the antibody results.
Authors
- Sukhvir Wright (ORCID: https://orcid.org/0000-0002-5464-3779)
- Ming Lim (ORCID: https://orcid.org/0000-0001-7738-8910)
- Alison Skippen
- Rob Forsyth (ORCID: https://orcid.org/0000-0002-5657-4180)
- Omar Abdel‐Mannan (ORCID: https://orcid.org/0000-0002-0796-9645)
- Yael Hacohen (ORCID: https://orcid.org/0000-0001-8490-9657)
- Eoin P. Flanagan (ORCID: https://orcid.org/0000-0002-6661-2910)
- Nee Na Kim (ORCID: https://orcid.org/0009-0007-6987-3060)
- Siobhan West
- Sithara Ramdas (ORCID: https://orcid.org/0000-0003-3790-2190)
- Cheryl Hemingway (ORCID: https://orcid.org/0000-0002-3899-3015)
- Asthik Biswas (ORCID: https://orcid.org/0000-0003-2010-9524)
- Thomas Rossor (ORCID: https://orcid.org/0000-0001-5472-1813)
- Olga Ciccarelli (ORCID: https://orcid.org/0000-0001-7485-1367)
- Kshitij Mankad (ORCID: https://orcid.org/0000-0001-5979-9337)
- Michael Eyre (ORCID: https://orcid.org/0000-0002-6704-5727)
- Dimitrios Champsas (ORCID: https://orcid.org/0000-0002-7275-4982)
- Dipak Ram (ORCID: https://orcid.org/0000-0001-8544-2534)
- Evangeline Wassmer (ORCID: https://orcid.org/0000-0002-2446-1106)
- Vanessa Wan Mun Lee (ORCID: https://orcid.org/0000-0003-3988-204X)
- Rachel Kneen (ORCID: https://orcid.org/0000-0002-8729-4122)
- Jacqueline A. Palace (ORCID: https://orcid.org/0000-0003-4779-6133)
- Manali V. Chitre
Institutions
- Great Ormond Street Hospital for Children NHS Foundation Trust (GB)
- University College London (GB)
Publication Details
- Journal
- Neurology Neuroimmunology & Neuroinflammation
- Published
- 2024-10-11
- DOI
- https://doi.org/10.1212/nxi.0000000000200323
- Citations
- 14
- Primary Topic
- Autoimmune Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.17
Funders
- Amgen
- Sanofi
- Biogen
- Teva Pharmaceutical Industries
- Alexion Pharmaceuticals
- PTC Therapeutics
- Berkeley Charitable Foundation
- Argenx
- Horizon Therapeutics
- Action Medical Research
- National Institute for Health and Care Research
- Rosetrees Trust
- MedDay Pharmaceuticals
- National Institutes of Health
- Genentech
- Chugai Pharmaceutical
- Medical Research Council
- Efficacy and Mechanism Evaluation Programme