Energy Associated With Dynamic Network Changes in Patients With Multiple Sclerosis and Cognitive Impairment
This study showed that it costs more energy for MS patients with cognitive impairment to dynamically change the functional network, possibly explaining why these transitions occur less frequently. In particular, transitions from a default mode network state to a visual network state were relevant for cognition in these patients. To further study the order of events leading to these network disturbances, future work should include longitudinal data across different disease stages.
Authors
- Maureen van Dam (ORCID: https://orcid.org/0000-0002-4639-5138)
- Ysbrand D. van der Werf (ORCID: https://orcid.org/0000-0003-2370-9584)
- Giuseppe Pontillo (ORCID: https://orcid.org/0000-0001-5425-1890)
- Christiaan H. Vinkers (ORCID: https://orcid.org/0000-0003-3698-0744)
- Tommy A.A. Broeders (ORCID: https://orcid.org/0000-0003-2884-2827)
- Frederik Barkhof (ORCID: https://orcid.org/0000-0003-3543-3706)
- Vasco Rauh
- Menno Michiel Schoonheim (ORCID: https://orcid.org/0000-0002-2504-6959)
- Joep Killestein (ORCID: https://orcid.org/0000-0002-6347-5957)
- Linda Douw (ORCID: https://orcid.org/0000-0001-7058-4062)
Institutions
- Amsterdam Neuroscience (NL)
- University College London (GB)
Publication Details
- Journal
- Neurology
- Published
- 2024-10-11
- DOI
- https://doi.org/10.1212/wnl.0000000000209952
- Citations
- 10
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.43
Funders
- Sanofi
- Biogen
- Teva Pharmaceutical Industries
- Celgene
- F. Hoffmann-La Roche
- Fondation pour l'Aide à la Recherche sur la Sclérose en Plaques
- Atara Biotherapeutics
- ZonMw
- Eisai
- IXICO
- MedDay Pharmaceuticals
- Amsterdam Neuroscience
- Eurostars