Poor long-term outcomes and abnormal neurodegeneration biomarkers after military traumatic brain injury: the ADVANCE study
TBI affected nearly a fifth of trauma-exposed personnel, related to worse mental health, motor and functional outcomes, as well as elevated plasma GFAP levels 8 years post-injury. This was absent after extracranial trauma, and showed a dose-response relationship with the severity of the injury.
Authors
- Nicola T. Fear (ORCID: https://orcid.org/0000-0002-5792-2925)
- Elena Veleva (ORCID: https://orcid.org/0009-0004-2440-8163)
- David Sharp (ORCID: https://orcid.org/0000-0003-4995-2240)
- Susie Schofield
- Grace Blissitt (ORCID: https://orcid.org/0009-0003-2840-797X)
- Karl Zimmerman (ORCID: https://orcid.org/0000-0003-1239-3414)
- Emma Coady
- Rhiannon Laban (ORCID: https://orcid.org/0000-0002-5926-8357)
- Anthony M. J. Bull (ORCID: https://orcid.org/0000-0002-4473-8264)
- Christopher John Boos (ORCID: https://orcid.org/0000-0002-3381-5068)
- Amanda Heslegrave (ORCID: https://orcid.org/0000-0002-7290-6405)
- Neil Graham (ORCID: https://orcid.org/0000-0002-0183-3368)
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0003-3930-4354)
- Lydia Orton (ORCID: https://orcid.org/0009-0001-2794-4138)
- Alexander Bennett
- Daniel Friedland
Institutions
- King's College London (GB)
- UK Dementia Research Institute (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
- Imperial College London (GB)
- University of Gothenburg (SE)
- Bournemouth University (GB)
Publication Details
- Journal
- Journal of Neurology Neurosurgery & Psychiatry
- Published
- 2024-10-11
- DOI
- https://doi.org/10.1136/jnnp-2024-333777
- Citations
- 13
- Primary Topic
- Traumatic Brain Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 5.03
Funders
- Forces in Mind Trust
- National Institute for Health and Care Research
- Academy of Medical Sciences
- National Lottery Community Fund
- UK Dementia Research Institute
- Medical Research Council
- NIHR Imperial Biomedical Research Centre