Predicting Vasospasm and Early Mortality in Severe Traumatic Brain Injury: A Model Using Serum Cytokines, Neuronal Proteins, and Clinical Data
Inflammatory cytokine levels after sTBI may have predictive value that exceeds conventional clinical variables for certain outcomes. IL-9, pulse rate, and eotaxin as well as Rotterdam score and age predict development of PTV. Eotaxin, IL-6, IL-12, and glucose were predictive of mortality. These results warrant validation in a prospective cohort.
Authors
- Eric A. Elster (ORCID: https://orcid.org/0000-0002-0981-2748)
- Jonathan Andrew Grossberg (ORCID: https://orcid.org/0000-0002-1152-8826)
- Pavlos Texakalidis (ORCID: https://orcid.org/0000-0002-8715-6651)
- Nicholas M. Boulis (ORCID: https://orcid.org/0000-0002-7271-3953)
- Rima S. Rindler (ORCID: https://orcid.org/0000-0002-2339-823X)
- Vivek Khatri
- Seth Schobel (ORCID: https://orcid.org/0000-0002-8967-257X)
- Sheila Eshraghi
- H. Thomas Robertson (ORCID: https://orcid.org/0000-0001-6536-3804)
- LaShondra De Yampert
- Scott F. Grey
Institutions
- Northwestern University (US)
- Henry M. Jackson Foundation (US)
- Uniformed Services University of the Health Sciences (US)
- Emory University (US)
- University of New Mexico (US)
- Walter Reed National Military Medical Center (US)
Publication Details
- Journal
- Neurosurgery
- Published
- 2024-10-11
- DOI
- https://doi.org/10.1227/neu.0000000000003224
- Primary Topic
- Traumatic Brain Injury and Neurovascular Disturbances
- Type
- article
- Field-Weighted Citation Impact
- 0.00