Harm effects in non-registered versus registered randomized controlled trials of medications: a retrospective cohort study of clinical trials
Medication-related harms may be understated in non-registered trials, and there was no obvious evidence that retrospective registration had a demonstrable benefit in reducing such selective or absent reporting. Prospective registration is highly recommended for future trials.
Authors
- Haitao Chu (ORCID: https://orcid.org/0000-0003-0932-598X)
- Yoon Kong Loke (ORCID: https://orcid.org/0000-0001-9109-2307)
- Sunita Vohra (ORCID: https://orcid.org/0000-0002-6210-7933)
- Su Golder (ORCID: https://orcid.org/0000-0002-8987-5211)
- Luis Furuya‐Kanamori (ORCID: https://orcid.org/0000-0002-4337-9757)
- Lifeng Lin (ORCID: https://orcid.org/0000-0002-3562-9816)
- Shiqi Fan (ORCID: https://orcid.org/0000-0002-2879-2295)
- Chang Xu (ORCID: https://orcid.org/0000-0002-2627-1250)
- Sheyu Li (ORCID: https://orcid.org/0000-0003-0060-0287)
Institutions
- University of East Anglia (GB)
- University of Minnesota (US)
- University of Arizona (US)
- University of Alberta (CA)
- The University of Queensland (AU)
- Second Military Medical University (CN)
- Pfizer (United States) (US)
- Sichuan University (CN)
- Eastern Hepatobiliary Surgery Hospital (CN)
- Statistical Research (United States) (US)
- University of York (GB)
Publication Details
- Journal
- BMC Medicine
- Published
- 2024-10-11
- DOI
- https://doi.org/10.1186/s12916-024-03621-7
- Primary Topic
- Health Systems, Economic Evaluations, Quality of Life
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Lanzhou University
- National Natural Science Foundation of China
- Anhui Medical University
- Sichuan University
- West China Hospital, Sichuan University