Safety and Efficacy of Prophylactic Topical Steroid Administration for Enfortumab Vedotin–related Cutaneous Toxicity
A drug called enfortumab vedotin (EV) used to treat advanced cancer of the urinary tract can cause severe skin reactions. We compared application of a steroid cream or Vaseline to the skin in five patients who were starting EV therapy. Three patients had an EV reaction on Vaseline-treated skin patches but not on steroid-treated skin patches. Because of these positive results, we are testing steroid cream at the start of EV treatment in a larger study.
Authors
- Satoru Yonekura (ORCID: https://orcid.org/0000-0003-4047-3016)
- Saeko Nakajima (ORCID: https://orcid.org/0000-0003-0831-1447)
- Kenji Kabashima (ORCID: https://orcid.org/0000-0002-0773-0554)
- Takashi Kobayashi (ORCID: https://orcid.org/0000-0002-9069-5736)
- Ryoichi Saito (ORCID: https://orcid.org/0000-0002-3163-8723)
- Takayuki Sumiyoshi (ORCID: https://orcid.org/0000-0001-5321-6014)
- Kimihiko Masui (ORCID: https://orcid.org/0000-0002-7841-1104)
- Takashi Nomura (ORCID: https://orcid.org/0000-0002-4004-1339)
- Takayuki Goto (ORCID: https://orcid.org/0000-0001-6537-3068)
- Kaoru Murakami (ORCID: https://orcid.org/0000-0002-4226-3867)
- Yuki Kita
Institutions
- Agency for Science, Technology and Research (SG)
- Kyoto University (JP)
Publication Details
- Journal
- European Urology Open Science
- Published
- 2024-10-11
- DOI
- https://doi.org/10.1016/j.euros.2024.09.011
- Citations
- 3
- Primary Topic
- Autoimmune Bullous Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.27
Funders
- Astellas Pharma