Crystal structures of two different multi-component crystals consisting of 1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline and fumaric acid
Two different multi-component crystals consisting of papaverine [1-(3,4-di-meth-oxy-benz-yl)-6,7-di-meth-oxy-iso-quinoline, C<sub>20</sub>H<sub>21</sub>NO<sub>4</sub>] and fumaric acid [C<sub>4</sub>H<sub>4</sub>O<sub>4</sub>] were obtained. Single-crystal X-ray structure analysis revealed that one, C<sub>20</sub>H<sub>21</sub>NO<sub>4</sub>·1.5C<sub>4</sub>H<sub>4</sub>O<sub>4</sub> (I), is a salt co-crystal composed of salt-forming and non-salt-forming mol-ecules, and the other, C<sub>20</sub>H<sub>21</sub>NO<sub>4</sub>·0.5C<sub>4</sub>H<sub>4</sub>O<sub>4</sub> (II), is a salt-co-crystal inter-mediate (<i>i.e.</i>, in an inter-mediate state between a salt and a co-crystal). In this study, one state (crystal structure at 100 K) within the salt-co-crystal continuum is defined as the 'inter-mediate'.
Authors
- Hiroshi Takiyama (ORCID: https://orcid.org/0000-0002-4564-0808)
- Noriyuki Takata (ORCID: https://orcid.org/0000-0003-2062-5043)
- Aya Sakon
- Hiroki Shibata
Institutions
- Tokyo University of Agriculture and Technology (JP)
Publication Details
- Journal
- Acta Crystallographica Section E Crystallographic Communications
- Published
- 2024-10-11
- DOI
- https://doi.org/10.1107/s2056989024009794
- Citations
- 1
- Primary Topic
- Crystal structures of chemical compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.16
Funders
- Chugai Pharmaceutical