TP53 mutation status and consensus molecular subtypes of colorectal cancer in patients from Rwanda
Our findings indicate a high frequency of TP53 variants in CRC patients from Rwanda. Importantly, these variants are enriched in the CMS2 subtype. This study, representing the second investigation into molecular alterations in patients with CRC from Rwanda and the first to explore TP53 mutations and CMS classification, provides valuable insights into the molecular landscape of CRC in this understudied population.
Authors
- Haruhiko Sugimura (ORCID: https://orcid.org/0000-0002-0779-3088)
- Schifra Uwamungu (ORCID: https://orcid.org/0009-0008-1546-2431)
- Gervais Ntakirutimana (ORCID: https://orcid.org/0000-0002-4745-8241)
- Felix Manirakiza (ORCID: https://orcid.org/0000-0002-9143-8758)
- Katsuhiro Yoshimura
- Yasuhiro Sakai (ORCID: https://orcid.org/0000-0001-7210-9249)
- Kazuya Shinmura (ORCID: https://orcid.org/0000-0003-4963-746X)
- Jean Bosco Surwumwe
- Rei Ishikawa (ORCID: https://orcid.org/0000-0003-4695-809X)
- Augustin Nzitakera (ORCID: https://orcid.org/0000-0002-7871-3954)
- Eric Rutaganda (ORCID: https://orcid.org/0000-0002-5863-7026)
- Vincent Dusabejambo
- Placide Kamali
- Delphine Uwamariya (ORCID: https://orcid.org/0000-0001-5207-2637)
- Belson Rugwizangoga (ORCID: https://orcid.org/0000-0001-6941-7320)
- Hisami Kato
- Marie Claire Ndayisaba
- Hidetaka Yamada (ORCID: https://orcid.org/0000-0003-4848-7201)
- Hirofumi Watanabe (ORCID: https://orcid.org/0000-0003-0657-5385)
- François Ngabonziza
- Benoit Seminega
- Ella Larissa Ndoricyimpaye (ORCID: https://orcid.org/0000-0002-5353-5493)
- Satoshi Baba (ORCID: https://orcid.org/0000-0003-4912-5712)
- André Mbonigaba
Institutions
- Sasaki Institute (JP)
- Hamamatsu University School of Medicine (JP)
- University of Rwanda (RW)
- Centre Hospitalier Universitaire de Kigali (RW)
- University of Gothenburg (SE)
- UCLouvain (BE)
Publication Details
- Journal
- BMC Cancer
- Published
- 2024-10-11
- DOI
- https://doi.org/10.1186/s12885-024-13009-8
- Citations
- 2
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.85
Funders
- Smoking Research Foundation
- Japan Society for the Promotion of Science
- Hospital Universiti Sains Malaysia