Macrophage Notch1 signaling modulates regulatory T cells via the TGFB axis in early MASLD
The immune mechanisms driving MASLD progression, particularly during the early stages of disease, are not fully understood, which limits the development of effective interventions. This study elucidated a novel mechanism by which hepatic macrophage Notch1 signaling modulated Tregs through the exosomal miR-142a-3p/TGFBR1 axis, contributing to the progression of MASLD. These findings provide a rationale for a potential immunological approach to treat MASLD in the future.
Authors
- Xiaoyu Dong (ORCID: https://orcid.org/0009-0009-8360-5112)
- Q. Y. Zhang (ORCID: https://orcid.org/0000-0002-5940-7441)
- Ruobin Zong
- Changyong Li (ORCID: https://orcid.org/0000-0003-4001-037X)
- Qintong Hu
- Kun Li (ORCID: https://orcid.org/0000-0001-8307-634X)
- Jie Ping (ORCID: https://orcid.org/0000-0002-9168-1811)
- Mengya Zhang (ORCID: https://orcid.org/0000-0002-1001-0427)
- Xiaoxing Huang (ORCID: https://orcid.org/0000-0002-1606-440X)
- Yue Ge (ORCID: https://orcid.org/0009-0006-6426-6344)
- Dongqin Xu
- Chaochen Jiang
Institutions
- Wuhan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
Publication Details
- Journal
- JHEP Reports
- Published
- 2024-10-11
- DOI
- https://doi.org/10.1016/j.jhepr.2024.101242
- Citations
- 5
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.93
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province
- Wuhan University
- Zhongnan Hospital of Wuhan University