Inhibiting the soluble epoxide hydrolase increases the EpFAs and ERK1/2 expression in the hippocampus of LiCl-pilocarpine post-status epilepticus rat model
This study demonstrates that inhibiting sEH with TPPU increases the levels of EETs, other EpFAs, and ERK1/2 expression in the hippocampus of a LiCl-pilocarpine-induced post-SE rat model. These findings suggest that the anti-seizure effect of TPPU may be mediated through the EETs-ERK1/2 pathway.
Authors
- Zihan Hu
- Xin Wang (ORCID: https://orcid.org/0000-0001-8079-8638)
- Weifeng Peng (ORCID: https://orcid.org/0000-0002-5713-0178)
- Yijun Shen (ORCID: https://orcid.org/0000-0003-3682-3378)
Institutions
- Sun Yat-sen University (CN)
- Fudan University (CN)
- Zhongshan Hospital of Xiamen University (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- YangPu Geriatric Hospital (CN)
Publication Details
- Journal
- IBRO Neuroscience Reports
- Published
- 2024-10-11
- DOI
- https://doi.org/10.1016/j.ibneur.2024.10.001
- Citations
- 1
- Primary Topic
- Eicosanoids and Hypertension Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 0.29
Funders
- Chongqing Medical University
- University of California, Davis