Reduction of myeloid‐derived suppressor cells in prostate cancer murine models and patients following white button mushroom treatment
White button mushroom (WBM) treatment resulted in a reduction in pro-tumoural MDSCs, notably polymorphonuclear MDSCs (PMN-MDSCs), along with activation of anti-tumoural T and NK cells. Human single immune cell gene expression profiling shed light on the molecular alterations induced by WBM, specifically on PMN-MDSCs. A proof-of-concept study combining WBM with PD-1 blockade in murine models revealed an additive effect on tumour regression and survival outcomes, highlighting the clinical relevance of WBM in cancer management.
Authors
- Sai Jin Xiao
- Xiwei Wu
- David Sadava
- Yin Chan (ORCID: https://orcid.org/0000-0001-9850-7261)
- Timothy W. Synold (ORCID: https://orcid.org/0000-0002-4075-2544)
- Timothy G. Wilson (ORCID: https://orcid.org/0009-0002-9647-7550)
- Shoubao Ma (ORCID: https://orcid.org/0000-0002-8397-7604)
- Shiuan Chen (ORCID: https://orcid.org/0000-0002-4482-6926)
- Jianhua Yu (ORCID: https://orcid.org/0000-0002-0326-3223)
- Paul Frankel (ORCID: https://orcid.org/0000-0001-8820-5809)
- Cary A. Presant (ORCID: https://orcid.org/0000-0002-4559-2826)
- Tanya Barauskas Dorff (ORCID: https://orcid.org/0000-0001-5990-298X)
- Jinhui Wang (ORCID: https://orcid.org/0000-0001-7024-3313)
- Xiaoqiang Wang (ORCID: https://orcid.org/0000-0002-1892-5613)
- Clayton Lau
- Kelly Wong
- Przemyslaw Twardowski
Institutions
- Saint John's Health Center (US)
- City of Hope (US)
- Beckman Research Institute
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1002/ctm2.70048
- Citations
- 12
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.89
Funders
- National Institutes of Health