CLINICAL AND ANAMNESTIC FEATURES AND MANAGEMENT OF PATIENTS WITH PULMONARY EMBOLISM IN THE KEMEROVO REGION IN COMPARISON WITH THE RESULTS OF THE “SIRENA” RUSSIAN REGISTRY

Highlights Patients with pulmonary embolism in the Kemerovo region have severe comorbidities and are older than those included in the Russian registry, however, these patients show a significantly lower rate of thromboembolism provoked by surgical interventions. The management of this group of patients in Kuzbass region includes active recanalization of the pulmonary artery branches with the help of fibrinolysis and surgical methods of thrombus removal. Aim. To comparatively analyze the features of diagnosis, treatment and outcomes in patients with pulmonary embolism (PE) from the Kuzbass patient registry and the results of the “SIRENA” Russian registry. Methods. The registry-based prospective single-center study included 185 patients with PE residing in the Kemerovo region. Moreover, we analyzed the data of 609 patients from the SIRENA registry (observational prospective multicenter study) who underwent a standard examination for patients with PE. Statistical processing of the study results was carried out using the MedCalc Version 16.2.1 software package (Softwa, Belgium). Results. Patients from the Kemerovo region have more adverse risk factors for pulmonary embolism compared with patients from the SIRENA registry: chronic heart failure (CHF) (23.30% versus 50.80%), coronary artery disease (CAD) (8.50%) versus 36.20%), acute stroke) in history (9.90% versus 12.40%), arterial hypertension (AH) (65.70% versus 78.40%), type 2 diabetes mellitus (type 2 diabetes) (15.20% vs. 20.50%), chronic kidney disease (CKD) (9.00% vs. 12.40%). Conclusion. Patients with PE in the Kemerovo region are characterized by a higher prevalence of cardiovascular diseases (coronary artery disease, arterial hypertension, chronic heart failure, venous thromboembolism in the anamnesis), older age, predominance of women, more frequent use of fibrinolysis compared with patients included in the SIRENA Russian registry. Only in Kuzbass specialists used surgical methods of thrombus removal.