Associations of metabolic heterogeneity of obesity with the risk of dementia in middle-aged adults: three prospective studies
Metabolic abnormality has a stronger association with dementia than obesity. Metabolically abnormal non-obesity and obesity, but not metabolically normal obesity, are associated with higher risks of incident dementia as compared with metabolically normal non-obesity. Recovering from an abnormal metabolic status to normal reduces the risk of dementia in populations without obesity. Our findings highlight the important role of metabolic status in the development of dementia and recommend the stratified management of obesity based on metabolic status.
Authors
- C. Z. Yuan (ORCID: https://orcid.org/0000-0002-1652-6686)
- Yimin Zhu (ORCID: https://orcid.org/0000-0001-8409-7636)
- Mingrui Duan
- Jie Shen (ORCID: https://orcid.org/0000-0001-6952-9541)
- Dan Zhou (ORCID: https://orcid.org/0000-0002-5313-8164)
- Tian Ge (ORCID: https://orcid.org/0000-0003-4738-0314)
- Yihong Ding (ORCID: https://orcid.org/0000-0002-0994-9103)
Institutions
- Harvard University (US)
- Sir Run Run Shaw Hospital (CN)
- Zhejiang Cancer Hospital (CN)
- Zhejiang Lab (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2024-10-11
- DOI
- https://doi.org/10.1186/s13195-024-01581-x
- Citations
- 5
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- Zhejiang University