High salt diet accelerates skin aging in wistar rats: an 8-week investigation of cell cycle inhibitors, SASP markers, and oxidative stress
The data suggest that a high salt diet causes skin aging by week 8. The effect of a high salt diet on skin aging is related to the level of oxidative stress and the expression of cell cycle inhibitors. Additionally, a potential protective mechanism may be at play, as evidenced by the reduced ET-1/NO ratio, which could help counteract the hypercoagulable state and support nutrient delivery to aging skin.
Authors
- Yixiao Chen (ORCID: https://orcid.org/0000-0001-8201-5887)
- Lina Xia (ORCID: https://orcid.org/0000-0001-5338-9126)
- Baihan Zeng
- Li Chen (ORCID: https://orcid.org/0000-0003-0738-5161)
- Nannan Liu (ORCID: https://orcid.org/0000-0002-3088-9387)
- Xile Peng
- Yilin Bai (ORCID: https://orcid.org/0009-0001-9697-3178)
- Xu Yang (ORCID: https://orcid.org/0000-0002-3615-3063)
Institutions
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2024-10-11
- DOI
- https://doi.org/10.3389/fbioe.2024.1450626
- Citations
- 5
- Primary Topic
- Skin Protection and Aging
- Type
- article
- Field-Weighted Citation Impact
- 2.67
Funders
- National Natural Science Foundation of China